There are Jesuit AIDS ministries in many sub-Saharan African countries. Each of the 10 Jesuit Provinces and Regions in Africa has AIDS programmes under way, some more than others. 

Jesuit AIDS ministry is very varied. Some initiatives are structured projects set up specifically to deal with HIV/AIDS while others are incorporated in wider Jesuit works, where dealing with AIDS is part and parcel of the daily mission, for example pastoral ministry in parishes.

So the Jesuit response to AIDS unfolds in a number of settings in both city and rural areas, including: youth centres; parishes; university chaplaincies; secondary and primary schools, including some set up for orphans and vulnerable children; hospitals and dispensaries; organisations supported by the Jesuits or run by the Christian Life Community (CLC), which is based on the spirituality of the founder of the Jesuits, St Ignatius of Loyola.

Some projects were created specifically to counter the challenges of HIV/AIDS. Examples are found in several countries including Burundi, Congo, Madagascar, Togo and Zimbabwe. The first four organise prevention activities and offer holistic services to people with HIV, orphans and vulnerable children and others who are affected; the fifth is more focused on youth prevention. All five advocate for access to treatment.